Immanuel Mifsud was born in Malta in 1967. He started writing poetry and prose when he was 16, and also began working with experimental theatre groups, directing his own plays and later works by Chekhov, Dario Fo, Max Frisch, Federico Garcia Lorca, David Mamet, Harold Pinter and Alfred Buttigieg.

Various works by Immanuel Mifsud have been translated an published in a number of European countries and USA.

Mifsud's prose immediately caught the attention of Maltese critics and won him the tag as the Maltese Generation-X writer. His 2005 short story collection Kimika (Chemistry), stirred a controversy for what was deemed as "pornographic literature" and the original publishers witheld the publication. The book went on sale later through a different publishing house. However reviews, including those from left leaning newspapers, kept censuring the book for its "filth", and the conservative English speaking papers never ran a review. Ironically Kimika placed second in the National Book Award for 2005.

Immanuel Mifsud writes also for children, having published a short story collection for children and a book of lullabies.

Immanuel Mifsud has participated in a number of prestigious literature festivals, such as the Festival de Poesia de la Mediterrania (Palma de Mallorca), Dnevi Poezija in Vina (Medana, Slovenia), Terceti Trnovski (Ljubljana, Slovenia), Dni Poezie a Vina (Valtice, Czech Republic), Siauliai Short Story Festival (Siauliai, Lithuania) and the celebrated Poetry Parnassus (London).

Some of his poems were published in eminent collections such as New European Poets (Graywolf Press), The Echoing Years (Waterford Institute of Technology), In Our Own Words: A Generation Defining Itself (MWE), Les poêtes de la méditerranée (Gallimard), and The World Record (Bloodaxe Books) amongst others.

In 2002, his short story collection L-Istejjer Strambi ta' Sara Sue Sammut (Sara Sue Sammut's Strange Stories) was awarded the National Book Award, and in 2011, Fl-Isem tal-Missier (u tal-Iben) (In the Name of the Father (and of the Son)) won the European Union Prize for Literature.